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安井　正人（やすい　まさと）

教授　2006年～

Keyword：
薬理学，Water Biology，アクアポリン，発達生理学

1989年　慶應義塾大学医学部　　卒業

　　　　聖路加国際病院小児科　レジデント

1992年　東京女子医科大学　母子総合医療センター新生児室 助手

1993年　スウェーデン王国カロリンスカ研究所大学院　博士課程
（1997年, Doctor of Philosophy)

1997年　米国ジョンズホプキンス大学医学部　ポストドクトラルフェロー

1999年　米国ジョンズホプキンス大学医学部　講師

2001年　米国ジョンズホプキンス大学医学部　助教授

2006年　慶應義塾大学　教授（医学部　薬理学教室）

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受　賞

2000年　Johns Hopkins Young Investigators Day, A. McGehee Harvey Prize受賞

2002年　Spa Foundation International Prize受賞

2004年　S&R Foundation Award受賞

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研究内容

構造生理学・薬理学。２００３年ノーベル化学賞受賞のAgre教授のもとで、水チャネル、アクアポリンの研究に従事してきた。水分子の動態（ふるまい）から生命現象を捉え直すことをテーマに研究に取り組む。（研究紹介ページを参照）

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主な論文

  1.  Nagaoka K, Ando F, Fujiki T, Abolhassani H, Hara Y, Yanagawa H, Suzuki S, Sakamaki Y, Oikawa D, Kikuchi H, Mandai S, Mori Y, Mori T, Susa K, Sohara E, Hoshino A, Ito T, Arakawa Y, Sasahara Y, Yasuda S, Abe Y, Yasui M, Tokunaga F, Kanegane H, Uchida S. LRBA organizes distinct vesicular traffcking systems in distal nephron segments for water and sodium conservation. Proc Natl Acad Sci USA. 123(18):e2525505123. DOI: 10.1073/pnas.2525505123. [PMID: 41981083] (2026)

  2. Kato D, Kameda H, Kinota N, Fujii T, Xiawei B, Simi Z, Takai Y, Chau S, Miyasaka Y, Mashimo T, Abe Y, Yasui M, Minowa K., Kudo K. Loss of aquaporin-4 impairs cerebrospinal fluid solute clearance through cerebrospinal fluid drainage pathways. Sci Rep. 14(1):27982. DOI: 10.1038/s41598-024-79147-y. [PMID: 39543281] (2024)

  3. Shinotsuka T, Miyazawa T, Karasawa K, Ozeki Y, Yasui M, Nuriya M. Stimulated Raman scattering microscopy reveals a unique and steady nature of brain water dynamics. Cell Rep Methods. 3(7):100519. DOI: 10.1016/j.crmeth.2023.100519. [PMID: 37533646] (2023)

  4. Ishida K, Yamada K, Nishiyama R, Hashimoto T, Nishida I, Abe Y, Yasui M, Iwatsubo T. Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration. J Exp Med. 219(3):e20211275. DOI:10.1084/jem.20211275. [PMID: 35212707] (2022)

  5. Momotake A, Mizuguchi T, Hishida M, Yamamoto Y, Yasui M, Nuriya M. Monitoring the morphological evolution of giant vesicles by azo dye-based sum-frequency generation (SFG) microscopy. Colloids Surf B Biointerfaces. 186:110716. DOI: 10.1016/j.colsurfb.2019.110716. [PMID: 31865122] (2020)

  6. Monai H, Wang X, Yahagi K, Lou N, Mestre H, Xu Q, Abe Y, Yasui M, Iwai Y, Nedergaard M and Hirase H. Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke. Proc Natl Acad Sci U S A. 116(22):11010-11019. DOI: 10.1073/pnas.1817347116. [PMID: 31097598] (2019)

  7. Mestre H, Hablitz LM, Xavier AL, Feng W, Zou W, Pu T, Monai H, Murlidharan G, Castellanos Rivera RM, Simon MJ, Pike MM, Plá V, Du T, Kress BT, Wang X, Plog BA, Thrane AS, Lundgaard I, Abe Y, Yasui M, Thomas JH, Xiao M, Hirase H, Asokan A, Iliff JJ, Nedergaard M. Aquaporin-4-dependent glymphatic solute transport in the rodent brain. Elife. 7:e40070. DOI: 10.7554/eLife.40070. [PMID: 30561329] (2018)

  8. Miyazaki-Komine K, Takai Y, Huang P, Kusano-Arai O, Iwanari H, Misu T, Koda K, Mitomo K, Sakihama T, Toyama Y, Fujihara K, Hamakubo T, Yasui M and Abe Y. High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with NMO-IgG. Br J Pharmacol. 173 ( 1 ) 103 - 114. DOI: 10.1111/bph.13340. [PMID: 26398585] (2016)

  9. Kato J, Hayashi MK, Aizu S, Yukutake Y, Takeda J, Yasui M. A general anesthetic propofol inhibits aquaporin-4 in the presence of Zn2+. Biochem. J. 454(2):275-82. DOI: 10.1042/BJ20130046. [PMID: 23772702] (2013)

  10.  Nuriya M and Yasui M. Endfeet serve as diffusion-limited subcellular compartments in astrocytes. J. Neurosci. 33(8):3692-8. DOI: 10.1523/JNEUROSCI.3050-12.2013. [PMID: 23426695] (2013)

  11. Ikeshima-Kataoka H, Abe Y, Abe T and Yasui M. Immunological function of aquaporin-4 in stab-wounded mouse brain in concert with a pro-inflammatory cytokine inducer, osteopont. Mol. Cell. Neurosci. (56):65-75. DOI: 10.1016/j.mcn.2013.02.002. [PMID: 23428384] (2013)

  12. Nuriya M, Shinotsuka T and Yasui M. Diffusion properties of molecules at the blood-brain interface: potential contributions of astrocyte endfeet to diffusion barrier functions. Cereb.Cortex. 23(9):2118-26. DOI: 10.1093/cercor/bhs198. [PMID: 22776675] (2013)

  13. Höfingera S, Yamamoto E, Hirano Y, Zerbettoa F, Narumie T, Yasuoka K and Yasuii M. Structural features of aquaporin 4 supporting the formation of arrays and junctions in biomembranes. Biochim. Biophys. Acta. 1818(9):2234-43. DOI: 10.1016/j.bbamem.2012.04.009. [PMID: 22554469] (2012)

  14. Ibata K, Takimoto S, Morisaku T, Miyawaki A and Yasui M. Analysis of aquaporin-mediated diffusional water permeability by coherent anti-stokes Raman scattering microscopy. Biophys. J. 101(9): 2277-83. DOI: 10.1016/j.bpj.2011.08.045. [PMID: 22067168] (2011)

  15. Kobayashi K, Miwa H and Yasui M. Inflammatory mediators weaken the amniotic membrane barrier through disruption of tight junctions. J. Physiol. 588(Pt24): 4859-69. DOI: 10.1113/jphysiol.2010.197764. [PMID: 21041526] (2010)

  16. Hirano Y, Okimoto N, Kadohira I, Suematsu M, Yasuoka K and Yasui M. Molecular mechanisms of how mercury inhibits water permeation through aquaporin-1: understanding by molecular dynamics simulation. Biophys. J. 98(8):1512-9. DOI: 10.1016/j.bpj.2009.12.4310. [PMID: 20409470] (2010)

  17. Yukutake Y, Hirano Y, Suematsu M and Yasui M. Rapid and Reversible Inhibition of Aquaporin-4 by Zinc. Biochemistry. 48(51):12059-61. DOI: 10.1021/bi901762y. [PMID: 19928950] (2009)

  18. Yasui M. pH regulated anion permeability of aquaporin-6. Handb. Exp. Pharmacol. 190:299-308. DOI: 10.1007/978-3-540-79885-9_15. [PMID: 19096784] (2009)

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