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研究成果

2024年
1)Yamaguchi S, Irie J, Mitsuishi M, Uchino Y, Nakaya H, Takemura R, Inagaki E, Kosugi S, Okano H, Yasui M, Tsubota K, Hayashi K, Yoshino J, Itoh H. Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men. Endocr J. 71(2):153-169. (2024)

DOI: 10.1507/endocrj.EJ23-0431. [PMID: 38191197]

2)Ogasawara J, Matsumoto N, Takeuchi Y, Yamashiro K, Yasui M, Ikegaya Y. Lengthened circadian rhythms in mice with self-controlled ambient light intensity. Sci Rep.14(1):7778. (2024)

DOI: 10.1038/s41598-024-58415-x. [PMID: 38565587]

3)Sato K, Hara-Chikuma M, Yasui M, Inoue J, Kim YG. Sufficient Water Intake Maintains the Gut Microbiota and Immune Homeostasis and Promotes Pathogen Elimination. ISCIENCE. 27(6):109903. (2024)

DOI: 10.1016/j.isci.2024.109903. [PMID: 38799550]

4)Morishita T, Nishizaki N, Taniguchi S, Sakai S, Kimura T, Mita M, Nakagawa M, Endo A, Ohtomo Y, Yasui M, Shimizu T, Sasabe J. Plasma D-asparagine and the D/L-serine ratio reflect chronic kidney diseases in children regardless of physique. Amino Acids. 56(1):38. (2024)

DOI: 10.1007/s00726-024-03400-x. [PMID: 38844708]

5)Yamamoto E, Joo K, Lee J, Sansom MSP, Yasui M. Molecular mechanism of anion permeation through aquaporin 6. Biophys J. 123(16):2496-2505. (2024)

DOI: 10.1016/j.bpj.2024.06.013. [PMID: 38894539]

6)Namatame C, Abe Y, Miyasaka Y, Takai Y, Matsumoto Y, Takahashi T, Mashimo T, Misu T, Fujihara K, Yasui M, Aoki M. Humanized-Aquaporin-4-Expressing Rat Created by Gene-Editing Technology and Its Use to Clarify the Pathology of Neuromyelitis Optica Spectrum Disorder. Int. J. Mol. Sci. 25(15), 8169. (2024)

DOI: 10.3390/ijms25158169. [PMID: 39125739]

7)Hong L, Tanaka M, Yasui M, Hara-Chikuma M. HSP90 promotes tumor associated macrophage differentiation during triple-negative breast cancer progression. Sci Rep. 14(1):22541. (2024)

DOI: 10.1038/s41598-024-73394-9. [PMID: 39341960]

8)Kato D, Kameda H, Kinota N, Fujii T, Xiawei B, Simi Z, Takai Y, Chau S, Miyasaka Y, Mashimo T, Abe Y, Yasui M, Minowa K, Kudo K. Loss of aquaporin-4 impairs cerebrospinal fluid solute clearance through cerebrospinal fluid drainage pathways. Sci Rep. 14(1):27982. (2024)

DOI: 10.1038/s41598-024-79147-y. [PMID: 39543281]

2023年

1)Osaki A, Aoyama M, Mita M, Hamase K, Yasui M, Sasabe J. Endogenous d-serine exists in the mammalian brain independent of synthesis by serine racemase. Biochem Biophys Res Commun​. 641:186-191. (2023)

DOI: 10.1016/j.bbrc.2022.12.037. [PMID: 36535077]

2)Murakami A, Tsuji K, Isoda M, Matsuo M, Abe Y, Yasui M, Okamura H, Tominaga K. Prolonged Light Exposure Induces Circadian Impairment in Aquaporin-4-Knockout Mice. J Biol Rhythms. 38(2):208-214. (2023)

DOI: 10.1177/07487304221146242. [PMID: 36694941]

3)Gonda Y, Matsuda A, Adachi K, Ishii C, Suzuki M, Osaki A, Mita M, Nishizaki N, Ohtomo Y, Shimizu T, Yasui M, Hamase K, Sasabe J. Mammals sustain amino acid homochirality against chiral conversion by symbiotic microbes.

Proc Natl Acad Sci USA. 120(15): e2300817120. (2023) 

DOI: 10.1073/pnas.2300817120. [PMID: 37014864]

4)Urushihata T, Takuwa H, Takahashi M, Kershaw J, Shibata S, Nitta N, Tachibana Y, Yasui M, Higuchi M, Obata T.

Distribution of intraperitoneally administered deuterium-labeled water in aquaporin-4-knockout mouse brain after middle cerebral artery occlusion. Front Neurosci. 16:1071272. (2023)

DOI: 10.3389/fnins.2022.1071272. [PMID: 36685250]

5)Wang Y, Suzuki R, Fujii A, Ieki K, Goda W, Yasui M, Abe Y. A tyrosine-based YXXΦ motif regulates the degradation of aquaporin-4 via both lysosomal and proteasomal pathways and is functionally inhibited by a 10-amino-acid sequence within its C-terminus. FEBS J. 290(10):2616-2635. (2023)

DOI: 10.1111/febs.16717. [PMID: 36597763]

6)  Kojić D, Simonova A, Yasui M. Removal of the ambient air features from fourier-Transform near-Infrared spectra.
J Quant Spectrosc Radiat Transf.
301(10):108538. (2023)

DOI: 10.1016/j.jqsrt.2023.108538.

7)  Shinotsuka T, Miyazawa T, Karasawa K, Ozeki Y, Yasui M, Nuriya M. Stimulated Raman scattering microscopy reveals a unique and steady nature of brain water dynamics. Cell Rep Methods. 3(7):100519.  (2023)

DOI: 10.1016/j.crmeth.2023.100519. [PMID: 37533646]

 

2022年

1)Oda R, Shou J, Zhong W, Ozeki Y, Yasui M, Nuriya M. Direct Visualization of General Anesthetic Propofol on Neurons by Stimulated Raman Scattering Microscopy. iScience. 25(3):103936. (2022)

DOI: 10.1016/j.isci.2022.103936. [PMID: 35252821]

2)Ishida K, Yamada K, Nishiyama R, Hashimoto T, Nishida I, Abe Y, Yasui M, Iwatsubo T. Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration. J Exp Med. 219(3): e20211275. (2022)

DOI: 10.1084/jem.20211275. [PMID: 35212707]

3)Imaizumi A, Obata T, Kershaw J, Tachibana Y, Abe Y, Shibata S, Nitta N, Aoki I, Yasui M, Higashi T. Quantitative measurement of diffusion-weighted imaging signal using expression-controlled aquaporin-4 cells: Comparative study of 2-compartment and diffusion kurtosis imaging models. PLoS One. 17(4): e0266465. (2022)

DOI: 10.1371/journal.pone.0266465. [PMID: 35439261]

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4)Shi Y, Yasui M, Hara-Chikuma M. AQP9 transports lactate in tumor-associated macrophages to stimulate an M2-like polarization that promotes colon cancer progression. Biochem Biophys Rep. 31:101317. (2022)

DOI: 10.1016/j.bbrep.2022.101317. [PMID: 35967760]

5)Nakamura K, Karasawa K, Yasui M, Nuriya M. Probing the Spatiotemporal Dynamics of Oxytocin in the Brain Tissue Using a Simple Peptide Alkyne-Tagging Approach. Anal Chem94(35):11990-11998. (2022)

DOI: 10.1021/acs.analchem.2c00452. [PMID: 36008880] 

 

6)Abe Y, Yasui M. Aquaporin-4 in Neuromyelitis Optica Spectrum Disorders: A Target of Autoimmunity in the Central Nervous System. Biomolecules. 12(4):591. (2022)

DOI: 10.3390/biom12040591, [PMID: 35454180]

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2021年

1)Nuriya M, Ashikari Y, Iino T, Asai T, Shou J, Karasawa K, Nakamura K, Ozeki Y, Fujimoto Y, Yasui M. Alkyne-Tagged Dopamines as Versatile Analogue Probes for Dopaminergic System Analysis. Anal Chem. 93(27):9345-9355. (2021)

DOI: 10.1021/acs.analchem.0c05403, [PMID: 34210142]

2)Ogasawara J, Ikenoue S, Yamamoto H, Sato M, Kasuga Y, Mitsukura Y, Ikegaya Y, Yasui M, Tanaka M, Ochiai D.

Deep neural network-based classification of cardiotocograms outperformed conventional algorithms. Sci Rep. 11(1):13367. (2021)

DOI: 10.1038/s41598-021-92805-9, [PMID: 34183748]

3)Ramadhanti J, Yamada T, Yasui M, Nuriya M. Differentially regulated pools of aquaporin-4 (AQP4) proteins in the cerebral cortex revealed by biochemical fractionation analyses. J Pharmacol Sci. 146(1):58-64. (2021)

DOI: 10.1016/j.jphs.2021.03.003, [PMID: 33858656]

4)Suzuki M, Sujino T, Chiba S, Harada Y, Goto M, Takahashi R, Mita M, Hamase K, Kanai T, Ito M, Waldor MK, Yasui M, Sasabe J. Host-microbe cross-talk governs amino acid chirality to regulate survival and differentiation of B cells. Sci Adv. 7(10):eabd6480. (2021)

DOI: 10.1126/sciadv.abd6480, [PMID: 33658193]

5)Glady A, Vandebroek A, Yasui M. Human keratinocyte-derived extracellular vesicles activate the MAPKinase pathway and promote cell migration and proliferation in vitro. Inflamm Regen. 41(1):4. (2021)

DOI: 10.1186/s41232-021-00154-x, [PMID: 33526070]

6)Chau S, Fujii A, Wang Y, Vandebroek A, Goda W, Yasui M, Abe Y. Di-lysine motif-like sequences formed by deleting the C-terminal domain of aquaporin-4 prevent its trafficking to the plasma membrane. Genes Cells. 26(3):152-164. (2021)

DOI: 10.1111/gtc.12829, [PMID: 33474763]

7)Vandebroek A, Yasui M. Cu 1+ , but not Cu 2+  is capable of inhibition of AQP4 permeability in an in vitro CHO cell based model. Biochem Biophys Rep. 28:101132. (2021)

DOI: 10.1016/j.bbrep.2021.101132, [PMID: 34557603]

8)Ishikawa T, Yasui M. Water Transportation During Cerebral Edema Formation and Aquaporin-4. Brain Nerve. 73(9):983-989. (2021)

DOI: 10.11477/mf.1416201875. [PMID: 34462369]

9)Shou J, Oda R, Hu F, Karasawa K, Nuriya M, Yasui M, Shiramizu B, Min W, Ozeki Y. Super-multiplex imaging of cellular dynamics and heterogeneity by integrated stimulated Raman and fluorescence microscopy. iScience. 24(8):102832. (2021)

DOI: 10.1016/j.isci.2021.102832. [PMID: 34381966]

10)Kato Y, Munćan J, Tsenkova R, Kojić D, Yasui M, Fan JY, Han JY. Aquaphotomics Reveals Subtle Differences between Natural Mineral, Processed and Aged Water Using Temperature Perturbation Near-Infrared Spectroscopy. Appl. Sci. 11(19): 9337. (2021)

DOI: 10.3390/app11199337.

11)Urushihata T, Takuwa H, Takahashi M, Kershaw J, Tachibana Y, Nitta N, Shibata S, Yasui M, Higuchi M, Obata T.

Exploring cell membrane water exchange in aquaporin-4-deficient ischemic mouse brain using diffusion-weighted MRI. Eur Radiol Exp. 5(1):44. (2021)

DOI: 10.1186/s41747-021-00244-y. [PMID: 34617156]

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