Publications | 慶應義塾大学医学部薬理学教室

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2024

Kato D, Kameda H, Kinota N, Fujii T, Xiawei B, Simi Z, Takai Y, Chau S, Miyasaka Y, Mashimo T, Abe Y, Yasui M, Minowa K, Kudo K. Loss of aquaporin-4 impairs cerebrospinal fluid solute clearance through cerebrospinal fluid drainage pathways. Sci Rep. 2024 Nov 14;14(1):27982. doi: 10.1038/s41598-024-79147-y.
Hong L, Tanaka M, Yasui M, Hara-Chikuma M. HSP90 promotes tumor associated macrophage differentiation during triple-negative breast cancer progression. Sci Rep. 2024 Sep 29;14(1):22541. doi: 10.1038/s41598-024-73394-9.
Kensuke Sato, Mariko Hara-Chikuma, Masato Yasui, Joe Inoue, Yun-Gi Kim.Sufficient Water Intake Maintains the Gut Microbiota and Immune Homeostasis and Promotes Pathogen Elimination.ISCIENCE (2024), doi: https://doi.org/10.1016/j.isci.2024.109903.
Ogasawara J, Matsumoto N, Takeuchi Y, Yamashiro K, Yasui M, Ikegaya Y.Lengthened circadian rhythms in mice with self-controlled ambient light intensity. Sci Rep . 2024 Apr 2;14(1):7778. doi: 10.1038/s41598-024-58415-x. (2024)
Yamaguchi S, Irie J, Mitsuishi M, Uchino Y, Nakaya H, Takemura R, Inagaki E, Kosugi S, Okano H, Yasui M, Tsubota K, Hayashi K, Yoshino J, Itoh H, Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men, Endocr J, 2024 Jan 6, doi: 10.1507/endocrj.EJ23-0431. Online ahead of print. (2024)
Morishita T, Nishizaki N, Taniguchi S, Sakai S, Kimura T, Mita M, Nakagawa M, Endo A, Ohtomo Y, Yasui M, Shimizu T, Sasabe J. Plasma D-asparagine and the D/L-serine ratio reflect chronic kidney diseases in children regardless of physique. Amino Acids. 2024 Jun 6;56(1):38. doi: 10.1007/s00726-024-03400-x.
Yamamoto E, Joo K, Lee J, Sansom MSP, Yasui M. Molecular mechanism of anion permeation through aquaporin 6. Biophys J. 2024 Jun 17:S0006-3495(24)00410-7. doi: 10.1016/j.bpj.2024.06.013.
Chihiro Namatame, Yoichiro Abe, Yoshiki Miyasaka, Yoshiki Takai, Yuki Matsumoto, Toshiyuki Takahashi, Tomoji Mashimo, Tatsuro Misu, Kazuo Fujihara, Masato Yasui and Masashi Aoki. Humanized-Aquaporin-4-Expressing Rat Created by Gene-Editing Technology and Its Use to Clarify the Pathology of Neuromyelitis Optica Spectrum Disorder. Int. J. Mol. Sci. 2024, 25(15), 8169; https://doi.org/10.3390/ijms25158169

2023

Gonda Y, Matsuda A, Adachi K, Ishii C, Suzuki M, Osaki A, Mita M, Nishizaki N, Ohtomo Y, Shimizu T, Yasui M, Hamase K, Sasabe J. Mammals sustain amino acid homochirality against chiral conversion by symbiotic microbes. Proc Natl Acad Sci U S A.2023 Apr 11; 120(15): e2300817120. doi: 10.1073/pnas.2300817120. Epub 2023 Apr 4.
Murakami A, Tsuji K, Isoda M, Matsuo M, Abe Y, Yasui M, Okamura H, Tominaga K. Prolonged Light Exposure Induces Circadian Impairment in Aquaporin-4-Knockout Mice. DOI: 10.1177/07487304221146242
Urushihata T, Takuwa H, Takahashi M, Kershaw J, Shibata S, Nitta N, Tachibana Y, Yasui M, Higuchi M, Obata T. Distribution of intraperitoneally administered deuterium-labeled water in aquaporin-4-knockout mouse brain after middle cerebral artery occlusion DOI: 10.3389/fnins.2022.1071272
Wang Y, Suzuki R, Fujii A, Ieki K, Goda W, Yasui M, Abe Y. A tyrosine-based YXXΦ motif regulates the degradation of aquaporin-4 via both lysosomal and proteasomal pathways and is functionally inhibited by a 10-amino-acid sequence within its C-terminus DOI: 10.1111/febs.16717
Osaki A, Aoyama M, Mita M, Hamase K, Yasui M, Sasabe J. Endogenous d-serine exists in the mammalian brain independent of synthesis by serine racemase. DOI: 10.1016/j.bbrc.2022.12.037

2022

Oda R, Shou J, Zhong W, Ozeki Y, Yasui M, Nuriya M. Direct Visualization of General Anesthetic Propofol on Neurons by Stimulated Raman Scattering Microscopy. iScience. 2022 Feb 17;25(3):103936. doi: 10.1016/j.isci.2022.103936.
Ishida K, Yamada K, Nishiyama R, Hashimoto T, Nishida I, Abe Y, Yasui M, Iwatsubo T. Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration. J Exp Med. 2022 Mar 7;219(3):e20211275. doi: 10.1084/jem.20211275.
Nakamura K, Karasawa K, Yasui M, Nuriya M. Probing the Spatiotemporal Dynamics of Oxytocin in the Brain Tissue Using a Simple Peptide Alkyne-Tagging Approach. Anal Chem., 94(35): 11990-11998.
Shi Y, Yasui M, Hara-Chikuma M. AQP9 transports lactate in tumor-associated macrophages to stimulate an M2-like polarization that promotes colon cancer progression. Biochem Biophys Rep. 2022 Aug 7;31:101317. doi: 10.1016/j.bbrep.2022.101317. eCollection 2022 Sep. PMID: 35967760
Abe Y, Yasui M. Aquaporin-4 in Neuromyelitis Optica Spectrum Disorders: A Target of Autoimmunity in the Central Nervous System. Biomolecules. 2022 Apr 17;12(4):591. doi: 10.3390/biom12040591. PMID: 35454180
Imaizumi A, Obata T, Kershaw J, Tachibana Y, Abe Y, Shibata S, Nitta N, Aoki I, Yasui M, Higashi T. Quantitative measurement of diffusion-weighted imaging signal using expression-controlled aquaporin-4 cells: Comparative study of 2-compartment and diffusion kurtosis imaging models.PLoS One. 2022 Apr 19;17(4):e0266465. doi: 10.1371/journal.pone.0266465. eCollection 2022. PMID: 35439261

2021

Nuriya M, Ashikari Y, Iino T, Asai T, Shou J, Karasawa K, Nakamura K, Ozeki Y, Fujimoto Y, Yasui M. Alkyne-Tagged Dopamines as Versatile Analogue Probes for Dopaminergic System Analysis. Anal Chem. 2021 Jul 13;93(27):9345-9355. doi: 10.1021/acs.analchem.0c05403. Epub 2021 Jul 1.
Ogasawara J, Ikenoue S, Yamamoto H, Sato M, Kasuga Y, Mitsukura Y, Ikegaya Y, Yasui M, Tanaka M, Ochiai D.Deep neural network-based classification of cardiotocograms outperformed conventional algorithms.Sci Rep. 2021 Jun 28;11(1):13367. doi: 10.1038/s41598-021-92805-9.
Ramadhanti J, Yamada T, Yasui M, Nuriya M. Differentially regulated pools of aquaporin-4 (AQP4) proteins in the cerebral cortex revealed by biochemical fractionation analyses. J Pharmacol Sci. 2021 May;146(1):58-64. doi: 10.1016/j.jphs.2021.03.003. Epub 2021 Mar 17.
Suzuki M, Sujino T, Chiba S, Harada Y, Goto M, Takahashi R, Mita M, Hamase K, Kanai T, Ito M, Waldor MK, Yasui M, Sasabe J. Host-microbe cross-talk governs amino acid chirality to regulate survival and differentiation of B cells. Sci Adv. 2021 Mar 3;7(10):eabd6480. doi: 10.1126/sciadv.abd6480. Print 2021 Mar.
Glady A, Vandebroek A, Yasui M. Human keratinocyte-derived extracellular vesicles activate the MAPKinase pathway and promote cell migration and proliferation in vitro. Inflamm Regen. 2021 Feb 2;41(1):4. doi: 10.1186/s41232-021-00154-x.
Chau S, Fujii A, Wang Y, Vandebroek A, Goda W, Yasui M, Abe Y. Di-lysine motif-like sequences formed by deleting the C-terminal domain of aquaporin-4 prevent its trafficking to the plasma membrane. Genes Cells. 2021 Mar;26(3):152-164. doi: 10.1111/gtc.12829.
Vandebroek A, Yasui M. Cu 1+, but not Cu 2+ is capable of inhibition of AQP4 permeability in an in vitro CHO cell based model. Biochem Biophys Rep. 2021 Sep 14;28:101132. doi: 10.1016/j.bbrep.2021.101132. PMID: 34557603
Ishikawa T, Yasui M. [Water Transportation During Cerebral Edema Formation and Aquaporin-4] Brain Nerve. 2021 Sep;73(9):983-989. doi: 10.11477/mf.1416201875.
Shou J, Oda R, Hu F, Karasawa K, Nuriya M, Yasui M, Shiramizu B, Min W, Ozeki Y. Super-multiplex imaging of cellular dynamics and heterogeneity by integrated stimulated Raman and fluorescence microscopy. iScience. 2021 Jul 9;24(8):102832. doi: 10.1016/j.isci.2021.102832.
Kato Y, Munćan J, Tsenkova R, Kojić D, Yasui M, Fan JY, Han JY. Aquaphotomics Reveals Subtle Differences between Natural Mineral, Processed and Aged Water Using Temperature Perturbation Near-Infrared Spectroscopy. Appl. Sci. 11(19): 9337 (2021)

2020

1）Momotake A, Mizuguchi T, Hishida M, Yamamoto Y, Yasui M, Nuriya M.
Monitoring the Morphological Evolution of Giant Vesicles by Azo Dye-based Sum-Frequency Generation (SFG) Microscopy.
Colloids and Surfaces B: Biointerfaces., 186.

2）Ichimura T, Nuriya M.
Symposium report: understanding biological systems with quantum science and technology.
Biophys Rev. 2020 Feb 28. doi: 10.1007/s12551-020-00655-y

3）Vandebroek AA, Yasui M.
Regulation of AQP4 in the Central Nervous System.
International Journal of Molecular Sciences 21(5) (2020)

4）Mizuguchi T, Momotake A, Hishida M, Yasui M, Yamamoto Y, Saiki T and Nuriya M.
Multimodal multiphoton imaging of the lipid bilayer by dye-based sum-frequency generation and coherent anti-Stokes Raman scattering. Analytical Chemistry. 92(8):5656-5660.

5）Nakamura Y, Watanabe H, Tanaka A, Yasui M, Nishihira J, Murayama N.
Effect of increased daily water intake and hydration on health in Japanese adults.
Nutrients. 23;12(4):1191.

6）Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Kawai K, Murakami M, Tanaka T, Goda W, Goto M, Yamamoto T, Hashimoto T, Yamada K, Shibata T, Misawa H, Mimura M, Tanaka KF, Miyakawa T, Iwatsubo T, Hata J, Niikura T, Yasui M.
Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model.
Acta Neuropathol Commun. 12;8(1):67

7）Mitsukura Y, Fukunaga K, Yasui M, Mimura M.
Sleep stage detection using only heart rate.
Health Informatics J. 26(1):376-387.

8）Mitsukura Y, Sumali B, Nagura M, Fukunaga K, Yasui M.
Sleep Stage Estimation from Bed Leg Ballistocardiogram Sensors. Sensors (Basel).
5;20(19): E5688.

9）Hara-Chikuma M, Tanaka M, Verkman A.S, Y Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Kawai K, Murakami M, Tanaka T, Goda W, Goto M, Yamamoto T, Hashimoto T, Yamada K, Shibata T, Misawa H, Mimura M, Tanaka KF, Miyakawa T, Iwatsubo T, Hata J, Niikura T, Yasui M.
Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury.
Nat Commun. 9;11(1):5666.

10）Nakamura Y, Tsuchiya T, Hara-Chikuma M, Yasui M, Fukui Y.
Identification of compounds in red wine that effectively upregulate aquaporin-3 as a potential mechanism of enhancement of skin moisturizing.
Biochem Biophys Rep. 23;24: 100864.

2019

1）Suzuki M, Gonda Y, Yamada M, Vandebroek AA, Mita M, Hamase K, Yasui M, Sasabe J.
Serum D-serine accumulat ion after proximal renal tubular damage involves　neutral amino acid transporter Asc-1.
Sci Rep.13;9(1):16705 (2019).

2）Nuriya M, Yoneyama H, Takahashi K, Leproux P, Cuderc V, Yasui M & Kano H.
Characterization of Intra/Extracellular Water States Probed by Ultrabroadband Multiplex Coherent Anti-Stokes Raman Scattering (CARS) Spectroscopic Imaging.
J. Phys. Chem. 123(17) :3928-3934 (2019).

3）Monai H, Wang X, Yahagi K, Lou N, Mestre H, Xu Q, Abe Y, Yasui M, Iwai Y, Nedergaard M and Hirase H.
Adrenergic Receptor Antagonism Induces Neuroprotection and Facilitates Recovery from Acute Ischemic Stroke.
Proc. Natl. Acad. Sci. USA. 116 (22): 11010-11019 (2019).

4）Ozawa Y, Toda E, Kawashima H, Homma K, Osada H, Nagai N, Abe Y, Yasui M, Tsubota K.
Aquaporin 4 Suppresses Neural Hyperactivity and Synaptic Fatigue and Fine-Tunes Neurotransmission to Regulate Visual Function in the Mouse Retina.
Mol Neurobiol. 56(12): 8124-8135(2019).

5）Hayashi MK, Nishioka T, Shimizu H, Takahashi K, Kakegawa W, Mikami T, Hirayama Y, Koizumi S, Yoshida S, Yuzaki M, Tammi M, Sekino Y, Kaibuchi K, Shigemoto-Mogami Y, Yasui M, Sato K.
Hyaluronan synthesis supports glutamate transporter activity.
J Neurochem.150(3): 249-263(2019)

2018

1）Glady A, Tanaka M, Moniaga CS, Yasui M and Hara-Chikuma M.
Involvement of NADPH oxidase 1 in UVB-induced cell signaling and cytotoxicity in human keratinocytes.
Biochem. Biophys. Rep., 14: 7-15.

2）Nuriya M, Yasui D, Yamada T, Aoki T and Yasui M.
Direct posttranslational modification of astrocytic connexin 43 proteins by the general anesthetic propofol in the cerebral cortex.
Biochem. Bioph. Res. Commun.., 497(2):734-741.

3)Nuriya M, Morita A, Shinotsuka T, Yamada T, Yasui M.
Norepinephrine induces rapid and long-lasting phosphorylation and redistribution of connexin 43 in cortical astrocytes.
Biochem Biophys Res Commun. 2018 Oct 12;504(4):690-697

4)Mizuguchi T, Yasui M, Nuriya M.
High-Resolution Plasma Membrane-Selective Imaging by Second Harmonic Generation.
iScience. 2018 Nov 30;9:359-366.

5)Mestre H, Hablitz LM, Xavier AL, Feng W, Zou W, Pu T, Monai H, Murlidharan G, Castellanos Rivera RM, Simon MJ, Pike MM, Plá V, Du T, Kress BT, Wang X, Plog BA, Thrane AS, Lundgaard I, Abe Y, Yasui M, Thomas JH, Xiao M, Hirase H, Asokan A, Iliff JJ, Nedergaard M.
Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
Elife., 7. e40070.

6)Obata T, Kershaw J, Tachibana Y, Miyauchi T, Abe Y, Shibata S, Kawaguchi H, Ikoma Y, Takuwa H, Aoki I, Yasui M.
Comparison of diffusion-weighted MRI and anti-Stokes Raman scattering (CARS) measurements of the inter-compartmental exchange-time of water in expression-controlled aquaporin-4 cells.
Sci Rep., 8(1):17954. (2018)

7)Tanaka S, Kojic D, Tsenkova R and Yasui M.
Quantification of anomeric structural changes of glucose solution using near-infrared spectra.
Carbohydr. Res., 463: 40-6.

8)Watanabe-Matsumoto S, Moriwaki Y, Okuda T, Ohara S, Yamanaka K, Abe Y, Yasui M, and Misawa H. Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis. Neurosci. Res. 133:48-57.

2017

1）Tomobe K, Yamamoto E, Yasui M and Yasuoka K.
Effects of temperature, concentration, and isomer on the hydration structure in monosaccharide solutions.
Phys. Chem. Chem. Phys.19(23):15239-15246.

2）Nuriya M, Takeuchi M and Yasui M.
Background norepinephrine primes astrocytic calcium responses to subsequent norepinephrine stimuli in the cerebral cortex.
Biochem. Bioph. Res. Commun. 483(1): 732–738.

3）Kojic D, Tsenkova R and Yasui M.
Improving Accuracy and Reproducibility of Vibrational Spectra for Diluted Solutions.
Anal. Chim. Acta. 955: 86-97

4）Abe Y, Goda W, Ikeshima-Kataoka H, Yasui M.
The Dual Effects of the Astrocyte-Specific Enhancer of the AQP4 M1 Promoter.
FEBS Lett., 591(23): 3906-3915.

5）Tomobe K, Yamamoto E, Kojic D, Sato Y, Yasui M, and Yasuoka K.
Origin of the blueshift of water molecules at interfaces of hydrophilic cyclic compounds.
Science Adv.,3,e1701400.

6）Hara T, Ohtomo Y, Endo A, Niijima S, Yasui M Shimizu T.
Evaluation of Urinary Aquaporin 2 and Plasma Copeptin as Biomarkers of Effectiveness of Desmopressin Acetate for the Treatment of Monosymptomatic Nocturnal Enuresis. J Urol., 198(4):921-927.

2016

1）Hiroko Ikeshima-Kataoka* and Masato Yasui
Correlation between astrocyte activity and recovery from blood-brain barrier breakdown caused by brain injury.
Neuroreport. 27(12): 894-900.

2）Hiroko Ikeshima-Kataoka.
Neuroimmunological Implications of AQP4 in Astrocytes.
Int. J. Mol. Sci. 17(8): E1306 . Review

3）Huang P, Takai Y, Kusano-Arai O, Ramadhanti J, Iwanari H, Miyauchi T, Sakihama T, Han JY, Aoki M, Hamakubo T, Fujihara K, Yasui M, and Abe Y.
The binding property of a mAb against the extracellular domains of AQP4 directs AQP4 toward endocytosis.
Biochem. Biophys. Rep. 7: 77-83.

4）Nuriya M, Fukushima S, Momotake A, Shinotsuka T, Yasui M & Arai T.
Multimodal two-photon imaging using a second harmonic generation-specific dye.
Nature Communications, 7: 11557.

5）Nuriya M & Hirase H.
Involvement of astrocytes in neurovascular communication.
Prog Brain Res. 2016;225:41-62.

6）Miyazaki-Komine K, Takai Y, Huang P, Kusano-Arai O, Iwanari H, Misu T, Koda K, Mitomo K, Sakihama T, Toyama Y, Fujihara K, Hamakubo T, Yasui M, Abe Y.
High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with NMO-IgG.
Br J Pharmacol. 173(1): 103-14.

7）Nishiyama S, Misu T, Nuriya M, Takano R, Takahashi T, Nakashima I, Yasui M, Itoyama Y, Aoki M, Fujihara K.
Complement-dependent and -independent aquaporin 4-antibody-mediated cytotoxicity in human astrocytes: Pathogenetic implications in neuromyelitis optica.
Biochem Biophys Rep. 7: 45-51.

2015

1）Kurosawa K, Misu T, Takai Y, Sato D K, Takahashi T, Abe Y, Iwanari H, Ogawa R, Nakashima I, Fujihara K, Hamakubo T, Yasui M and Aoki M.
Severely exacerbated neuromyelitis optica rat model with extensive astro cytopathy by high affinity anti-aquaporin-4 monoclonal antibody.
Acta Neuropathol Com. 3(1): 82. (2015)

2）Sohma Y, Hwang TC.
Cystic fibrosis and the CFTR anion channel.
In: Handbook of Ion Channels. Eds. Zheng & Trudeau, CRC Press Taylor & Francis Books Inc. pp. 627 – 648. (2015) ISBN-10: 1466551402

3) Yasui M.
Roles of Aquaporins in Brain Disorders.
Brain Nerve. 67(6):733-8 (2015)

4）Hayashi MK, Yasui M.
The transmembrane transporter domain of glutamate transporters is a process tip localizer.
Sci Rep. 5:9032 (2015)

5）Yamamoto E, Akimoto T, Yasui M, Yasuoka K.
Origin of 1/f noise in hydration dynamics on lipid membrane surfaces.
Sci Rep. 5:8876. (2015)

6）Miyauchi T, Yamamoto H, Abe Y, Yoshida GJ, Rojek A, Sohara E, Uchida S, Nielsen S, Yasui M.
Dynamic subcellular localization of aquaporin-7 in white adipocytes.
FEBS Lett. 589(5):608-14. (2015)

7）Ikeshima-Kataoka H, Abe Y, Yasui M.
Aquaporin 4-Dependent expression of glial fibrillary acidic protein and tenascin-C in activated astrocytes in stab wound mouse brain and in primary culture.
J Neurosci Res. 93(1):121-9.(2015)

2014

1）Fukuhara S, Matsuzaki J, Tsugawa H, Masaoka T, Miyoshi S, Mori H, Fukushima Y, Yasui M, Kanai T, Suzuki H.
Mucosal expression of aquaporin-4 in the stomach of histamine type 2 receptor knockout mice and Helicobacter pylori-infected mice.
J Gastroenterol Hepatol. 29 Suppl 4:53-9. (2014)

2）Furukawa-Hagiya T, Yoshida N, Chiba S, Hayashi T, Furuta T, Sohma Y, Sakurai M.
Water-meditated forces between the nucleotide binding domains generate the power stroke in an ABC transporter.
Chemical Physics Letters in press.

3）Guo JH, Chen H, Ruan YC, Zhang XL, Zhang XH, Fok KL, Tsang LL, Yu MK, Huang WQ, Sun X, Chung YW, Jiang X, Sohma Y, Chan HC.
Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR.
Nat Commun. 15;5: 4420. (2014)

4）Kojić D, Tsenkova R, Tomobe K, Yasuoka K, Yasui M.
Water Confined in the Local Field of Ions.
Chemphyschem. 15(18):4077-86.(2014)

5）Gondo A, Shinotsuka T, Morita A, Abe Y, Yasui M, Nuriya M.
Sustained Downregulation of β-Dystroglycan and Associated Dysfunctions of Astrocytic Endfeet in Epileptic Cerebral Cortex.
J Biol Chem. 289(44):30279-88.(2014)

6）Kato J, Takai Y, Hayashi MK, Kato Y, Tanaka M, Sohma Y, Abe Y, Yasui M.
Expression and localization of aquaporin-4 in sensory ganglia.
Biochem. Biophys. Res. Commun.451(4):562-7. (2014)

7）Kato Y, Miyauchi T, Abe Y, Kojić D, Tanaka M, Chikazawa N, Nakatake Y, Ko SB, Kobayashi D, Hazama A, Fujiwara S, Uchida T, Yasui M.
Unprecedented cell-selection using ultra-quick freezing combined with aquaporin expression.
PLoS One. 9(2):e87644. (2014)

8）Shinotsuka T, Yasui M, Nuriya M.
Astrocytic gap junctional networks suppress cellular damage in an in vitro model of ischemia.
Biochem. Biophys. Res. Commun.444(2):171-6. (2014)

9）Yamamoto E, Akimoto T, Yasui M and Yasuoka K.
Origin of subdiffusion of water molecules on cell membrane surfaces.
Sci. Rep. 4:4720. (2014)

10）Yamamoto E, Akimoto T, Hirano Y, Yasui M and Yasuoka K.
1/ f fluctuations of amino acids regulate water transportation in aquaporin 1. Physical Review E Stat Nonlin Soft Matter Phys. 89(2):022718.(2014)

11）Arai N, Akimoto T, Yamamoto E, Yasui M and Yasuoka K.
Poisson property of the occurrence of flip-flops in a model membrane.
J. Chem. Phys. 140(6):064901. (2014)

2013

1）Ramadhanti J, Huang P, Kusano-Arai O, Iwanari H, Sakihama T, Misu T, Fujihara K, Hamakubo T, Yasui M and Abe Y.
A novel monoclonal antibody against the C-terminal region of aquaporin-4. Monoclon.Antib.Immunodiagn.Immunother. in32:270-276. (2013)

2）Miyazaki K, Abe Y, Iwanari H, Suzuki Y, Kikuchi T, Ito T, Kato J, Kusano-Arai O, Takahashi T, Nishiyama S, Ikeshima-kataoka H, Tsuji T, Arimitsu T, Kato Y, Sakihama T, Toyama Y, Fujihara K, Hamakubo T and Yasui M.
Establishment of Monoclonal Antibodies Against the Extracellular Domain That Block Binding of NMO-IgG to AQP4.
J Neuroimmunol. 260:107-116 (2013)

3）Nuriya M and Yasui M.
Endfeet serve as diffusion-limited subcellular compartments in astrocytes.
J. Neurosci. 33(8):3692-8. (2013)

4）Kagawa R, Hirano Y, Yasuoka K and Yasui M.
Dynamic interactions of cations, water and lipids influence on membrane fluidity.
J.Membr. Sci. in press (2013)

5）Ikeshima-Kataoka H, Abe Y, Abe T and Yasui M.
Immunological function of aquaporin-4 in stab-wounded mouse brain in concert with a pro-inflammatory cytokine inducer, osteopont.
Mol. Cell. Neurosci. 7431(13):00020-1. (2013)

6）Nuriya M, Shinotsuka T and Yasui M.
Diffusion properties of molecules at the blood-brain interface: potential contributions of astrocyte endfeet to diffusion barrier functions.
Cereb.Cortex. in press (2013)

7）Sohma Y, Yu YC, Miki H, Nakamura Y, Hanyuda A, Lin HY, Yasui M, Bompadre SG and Hwang TC.
Pharmaceutical implications of curcumin in the development of drugs for CF pharmacotherapy: combined effects with genistein In: Curcumin: Biosynthesis, Medicinal Uses and Health Benefits. Editors Sasaki J & Kichida M.
Nova Science Publishers. Hauppauge. NY. USA. in press (2013)

8）Sohma Y, Yu YC and Hwang TC.
Curcumin and Genistein: The combined effects on disease-associated CFTR mutants and their clinical implications.
Curr. Pharm. Des. in press (2013)

9）Yang Y, Sohma Y, Nourian Z, Ella SR, Li M, Stupica A, Korthuis RJ, Davis MJ, Braun AP and Hill MA.
Mechanisms underlying regional differences in the Ca2+ sensitivity of BKCa current in arteriolar smooth muscle.
J. Physiol. 591(PT5):1277-93. (2013)

10）Furukawa-Hagiya T, Furuta T, Chiba S, Sohma Y and Sakurai M.
The power stroke driven by ATP binding in CFTR as studied by molecular dynamics simulations.
J. Phys. Chem. B. 117(1):83-93. (2013)

11）Yamamoto E, Akimoto T, Hirano Y, Yasui M and Yasuoka K.
Power-law trapping of water molecules on the lipid-membrane surface induces water retardation.
Phys. Rev. E, 87, 052715. (2013)

12）Kato J, Hayashi MK, Aizu S, Yukutake Y, Takeda J, Yasui M.
A general anesthetic propofol inhibits aquaporin-4 in the presence of Zn2+.
Biochem. J. in press (2013)

13）Nanatani K, Shijuku T, Akai M, Yukutake Y, Yasui M, Hamamoto S, Onai K, Morishita M, Ishiura M, Uozumi N.
Characterization of the role of a mechanosensitive channel in osmotic down shock adaptation in Synechocystis sp PCC 6803.
Channels (Austin). in press (2013)

14）Yu YC, Sohma Y, Takimoto S, Miyauchi T, Yasui M.
Direct visualization and quantitative analysis of water diffusion in complex biological tissues using CARS microscopy.
Sci Rep. 3:2745. (2013)

2012

1）Akai M, Onai K, Morishita M, Mino H, Shijuku T, Maruyama H, Arai F, Itoh S, Hazama A, Checchetto V, Szabo I, Yukutake Y, Suematsu M, Yasui M, Ishiura M and Uozumi N. Aquaporin AqpZ is Involved in Cell Volume Regulation and Sensitivity to Osmotic Stress in Synechocystis sp. PCC 6803. J.Bacteriol. 194(24):6828-36. (2012)

2）Yoshinaga S, Ohkubo T, Sasaki S, Nuriya M, Ogawa Y, Yasui M, Tabata H and Nakajima K. A phosphatidylinositol lipids system, lamellipodin, and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex. J. Neurosci. 32(34):11643-56. (2012)

3）Yasui M. Role of aquaporin, water channel in the brain. Nihon Yakurigaku Zasshi. 139(5):230. (2012)

4）Yamamoto E, Akimoto T, Shimizu H, Hirano Y, Yasui M and Yasuoka K. Diffusive nature of xenon anesthetic changes properties of a lipid bilayer: molecular dynamics simulations. J. Phys. Chem. B. 116(30):8989-95. (2012)

5）Yamamoto E, Akimoto T, Hirano Y, Yasui M and Yasuoka K. Target search processes in cells are optimized by low diffusivity and trapping near membrane surfaces. Submitted (2012)

6）Yamamoto M, Takeya M, Ikeshima-Kataoka H, Yasui M, Kawasaki Y, Shiraishi M, Majima E, Shiraishi S, Uezono Y, Sasaki M and Eto K. Increased expression of aquaporin-4 with methylmercury exposure in the brain of the common marmoset. J. Toxicol. Sci. 37(4):749-63. (2012)

7）Höfingera S, Yamamoto E, Hirano Y, Zerbettoa F, Narumie T, Yasuoka K and Yasui M. Structural features of aquaporin 4 supporting the formation of arrays and junctions in biomembranes. Biochim. Biophys. Acta. 1818(9):2234-43. (2012)

8）Hiyoshi H, Abdelhady S, Segerström L, Sveinbjörnsson B, Nuriya M, Lundgren TK, Desfrere L, Miyakawa A, Yasui M, Kogne P, Johnsen J I, Andäng M and Uhlén P. Quiescence and γH2AX in neuroblastoma are regulated by ouabain/Na, K-ATPase. Br. J. Cancer. 106(11): 1807-15. (2012)

9）Abe Y, Ikeshima-Kataoka H, Goda W, Niikura T and Yasui M. An astrocyte-specific enhancer of the aquaporin-4 gene functions through a consensus sequence of POU transcription factors in concert with multiple upstream elements. J. Neurochem. 120(6):899-912. (2012)

10）Jih KY, Sohma Y and Hwang TC. Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation. J. Gen. Physiol. 140(4):347-59. (2012)

11）Kang MG, Nuriya M, Guo Y, Martindale KD, Lee DZ and Huganir RL. Proteomic analysis of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor complexes. J. Biol. Chem. 287(34)28632-45. (2012)

12）Jih KY, Sohma Y, Li M and Hwang TC. Identification of a novel post-hydrolytic state in CFTR gating. J. Gen. Physiol.139(5):359-70. (2012)

13）Hayasaki H, Sohma Y, Kanbara K and Otsuki Y. Heterogenous GABA(B) receptor-mediated pathways are involved in the local GABAergic system of the rat trigeminal ganglion: possible involvement of KCTD proteins. Neuroscience. 218:344-58. (2012)

2011

1）Ibata K, Takimoto S, Morisaku T, Miyawaki A and Yasui M. Analysis of aquaporin-mediated diffusional water permeability by coherent anti-stokes Raman scattering microscopy. Biophys. J. 101(9): 2277-83. (2011)

2）Akimoto T, Yamamoto E, Yasuoka K, Hirano Y and Yasui M. Non-Gaussian fluctuations resulting from power-law trapping in a lipid bilayer. Phys. Rev. Lett. 107(17):178103. (2011)

3）Akai M, Onai K, Kusano M, Sato M, Redestig H, Toyooka K, Morishita M, Miyake H, Hazama A, Checchetto V, Szabo I, Matsuoka K, Saito K, Yasui M, Ishiura M and Uozumi N. Plasma membrane aquaporin AqpZ protein is essential for glucose metabolism during photomixotrophic growth of Synechocystis sp. PCC 6803. J. Biol. Chem. 286(28):25224-35. (2011)

4）Yu YC, Miki H, Nakamura Y, Hanyuda A, Matsuzaki Y, Abe Y, Yasui M, Tanaka K, Hwang TC, Bompadre SB and Sohma Y. Curcumin and genistein additively potentiate G551D-CFTR. J. Cyst. Fibros. 10(4):243-52. (2011)

5）Kobayashi K, Miwa H and Yasui M. Progesterone maintains amniotic tight junctions during midpregnancy in mice. Mol. Cell. Endocrinol. 337 (1-2):36-42. (2011)

6）Kobayashi K, Umezawa K and Yasui M. Apoptosis in mouse amniotic epithelium is induced by activated macrophages through the TNF receptor type 1/TNF pathway. Biol. Reprod. 84(2): 248-54. (2011)

7）Yang YM, Aitoubah J, Lauer AM, Nuriya M, Takamiya K, Jia Z, May BJ, Huganir RL and Wang LY. GluA4 is indispensable for driving fast neurotransmission across a high-fidelity central synapse. J. Physiol. 589(Pt17):4209-27. (2011)

8）Cai Z, Sohma Y, Bompadre SG, Sheppard DN and Hwang TC. Application of high-resolution single-channel recording to functional studies of cystic fibrosis mutants. Methods. Mol. Biol. 741:419-41. (2011)

9）Rajan RS, Tsumoto K, Tokunaga M, Tokunaga H, Kita Y, Arakawa T. Chemical and pharmacological chaperones: application for recombinant protein production and protein folding diseases. Curr. Med. Chem. 18(1):1-15 (2011)

2010

1）Shimizu H, Yu YC, Kono K, Kubota T, Yasui M, Li M, Hwang TC and Sohma Y. A stable ATP binding to the nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR. J. Physiol. Sci. 60(5): 353-62. (2010)

2）Kobayashi K, Miwa H and Yasui M. Inflammatory mediators weaken the amniotic membrane barrier through disruption of tight junctions. J. Physiol. 588(Pt24): 4859-69. (2010)

3）Kobayashi K and Yasui M. Cellular and subcellular localization of aquaporins 1, 3, 8, and 9 in amniotic membranes during pregnancy in mice. Cell. Tissue. Res. 342(2): 307-16. (2010)

4）Matsuzaki J, Suzuki H, Minegishi Y, Sugai E, Tsugawa H, Yasui M and Hibi T. Acid suppression by proton pump inhibitors enhances aquaporin-4 and KCNQ1 expression in gastric fundic parietal cells in mouse. Dig. Dis. Sci. 55(12):3339-48. (2010)

5）Ito T, Nuriya M and Yasui M. Regulation of Kv2.1 phosphorylation in an animal model of anoxia. Neurobiol. Dis. 38(1):85-91. (2010)

6）Nuriya M and Yasui M. Membrane potential dynamics of axons in cultured hippocampal neurons probed by second-harmonic-generation imaging. J. Biomed. Opt. 15(2):020503. (2010)

7）Hirano Y, Okimoto N, Kadohira I, Suematsu M, Yasuoka K and Yasui M. Molecular mechanisms of how mercury inhibits water permeation through aquaporin-1: understanding by molecular dynamics simulation. Biophys. J. 21;98(8):1512-9. (2010)

8）Kobayashi K, Kadohira I, Tanaka M, Yoshimura Y, Ikeda K and Yasui M. Expression and distribution of tight junction proteins in human amnion during late pregnancy. Placenta. 31(2):158-62. (2010)

9）Yukutake Y and Yasui M. Regulation of water permeability through aquaporin-4. Neuroscience. 168(4):885-91. (2010)

10）Shiraki K, Hirano A, Kita Y, Koyama AH, Arakawa T. Potential application of aeginine in interaction analysis. Drug. Discov. Ther. 4(5):326-33. (2010)

11）Kopeikin Z, Sohma Y, Li M and Hwang TC. On the mechanism of CFTR inhibition by a thiazolidinone derivative. J. Gen. Physiol. 136(6):659-71. (2010)

12）Kobayashi K, Suzuki T, Nomoto Y, Tada Y, Miyake M, Hazama A, Wada I, Nakamura T and Omori K. A tissue-engineered trachea derived from a framed collagen scaffold, gingival fibroblasts and adipose-derived stem cells. Biomaterials. 31(18):4855-63. (2010)

13）Arakawa T, Futatsumori-sugai M, Tsumoto K, Kita Y, Sato H and Ejima D. MEP HyperCel chromatography Ⅱ: binding, washing and elution. Protein . Expr. Purif. 71(2):168-73. (2010)

14）Arakawa T, Hirano A, Shiraki K, Kita Y and Koyama AH. Stabilizing and destabilizing effects of arginine on deoxyribonucleic acid. Int. J. Biol. Macromol. 46(2):217-22. (2010)

15）Hirano A, Shiraki K, Niikura T, Arakawa T and Kita Y. Structure changes of natively disordered Humanin in the presence of lipid. Int. J. Biol. Macromol. 46(3):375-9. (2010)

2009

1）Yukutake Y, Hirano Y, Suematsu M and Yasui M. Rapid and Reversible Inhibition of Aquaporin-4 by Zinc. Biochemistry. 48(51):12059-61. (2009)

2）Kobayashi K, Inai T, Shibata Y and Yasui M. Dynamic changes in amniotic tight junctions during pregnancy. Placenta. 30(10):840-7. (2009)

3）Laforenza U, Gastaldi G, Polimeni M, Tritto S, Tosco M, Ventura U, Scaffino M F and Yasui M. Aquaporin-6 is expressed along the rat gastrointestinal tract and upregulated by feeding in the small intestine. BMC Physiol. 9:1-12.(2009)

4）Arimitsu T, Nuriya M, Ikeda K, Takahashi T and Yasui M. Activity-dependent regulation of HCN1 protein in cortical neurons. Biochem Biophys Res Commun. 387(1):87-91. (2009)

5）Tatsumi K, Tsuji S, Miwa H, Morisaku T, Nuriya M, Orihara M, Kaneko K, Okano H and Yasui M. Drosophila big brain does not act as a water channel, but mediates cell adhesion. FEBS Lett. 583(12): 2077-82. (2009)

6）Rabaud NE, Song L, Wang Y, Agre P, Yasui M and Carbrey J M. Aquaporin 6 binds calmodulin in a calcium-dependent manner. Biochem. Biophys. Res. Commun. 383(1):54-7. (2009)

7）Narumi S, Muroya K, Abe Y, Yasui M, Asakura Y, Adachi M and Hasegawa T. TSHR mutations as a cause of congenital hypothyroidism in Japan: a population-based genetic epidemiology study. J. Clin. Endocrinol. Metab. 94(4):1317-23. (2009)

8）Yasui M. pH regulated anion permeability of aquaporin-6. Handb. Exp. Pharmacol. 190:299-308. (2009)

9）Liu W, Deng C, McLaughlin CR, Fagerholm P, Lagali NS, Heyne B, Scaiano JC, Watsky MA, Kato Y, Munger R, Shinozaki N, Li F and Griffith M. Collagen-phosphorylcholine interpenetrating network hydrogels as corneal substitutes. Biomaterials. 30(8):1551-9. (2009)

10）Arakawa T, Kita Y, Sato H and Ejima D. MEP chromatography of antibody and Fc-fusion protein using aqueous arginine solution. Protein. Expr. Purif. 63(2):158-63. (2009)

11）Arakawa T, Kita Y, Sato H and Ejima D. Stress-free chromatography : affinity chromatography. Curr. Pharm. Viotechnol. 10(4):456-60. (2009)

12）Arakawa T, Kita Y and Koyama AH. Synergistic virus inactivation effects of arginine. Biotechnol. J. 4(2):174-8. (2009)

13）Arakawa T, Kita Y and Ejima D. Stress-free chromatography : IEC and HIC. 10(4):461-3. (2009)

14）Arisaka F, Arakawa T, Niikura T and Kita Y. Active form of neuroprotective Humanin, HN, and inactive analog, S7A-HN, are monomeric and disordered in aqueous phosphate solution at pH 6.0 ; No correlation of solution structure with activity. 16(2):132-7. (2009)

15）Arakawa T, Niikura T, Arisaka F and Kita Y. Short neuroprotective peptides, ADNF9 and NAP, are structurally disordered and monomeric in PBS. Int. J. Biol. Macromol 45(1):8-11. (2009)

16）Okano W, Nomoto Y, Wada I, Kobayashi K, Miyake M, Nakamura T and Omori K. Bioengineered trachea with fibroblasts in a rabbit model. Ann. Otol. Rhinol. Laryngol. 118(11):796-804. (2009)

17）Ikeshima-Kataoka H, Wada A, Ishiwata K, Watanabe N and Saito S. Cloning and expression of cDNA for interleukin 4 from the MSKR inbred strain of Mus musculus molossinus. In. Vivo. 23(2):277-80. (2009)

18）Hayashi MK, Tang C, Verpelli C, Narayanan R, Stearns MH, Xu RM, Li H, Sala C and Hayashi Y. The postsynaptic density proteins Homer and Shank form a polymeric network structure. Cell. 137(1):159-71. (2009)

19）Tsai MF, Shimizu H, Sohma Y, Li M and Hwang TC. State-dependent modulation of CFTR gating by pyrophosphate. 133(4):405-19. (2009)

20）Akamatsu K, Shibata MA, Ito Y, Sohma Y, Azuma H and Otsuki Y. Riluzole induces apoptotic cell death in human prostate cancer cells via endoplasmic reticulum stress. Anticancer. Res. 29(6):2195-204. (2009)

21）Samani K, Wu G, Ai T, Shuraih M, Mathuria NS, Li Z, Sohma Y, Purevjav E, Xi Y, Towbin JA, Cheng J and Vatta M. A novel SCN5A mutation V1340Ⅰ in Brugada syndrome augmenting arrhythmias during febrile illness. Heart. Rhythm. 6(9):1318-26. (2009)

2008

1）Kadohira I, Abe Y, Nuriya M, Sano K, Tsuji S, Arimitsu T, Yoshimura Y and Yasui M. Phosphorylation in the C-terminal domain of Aquaporin-4 is required for Golgi transition in primary cultured astrocytes. Biochem. Biophys. Res. Commun. 377(2): 463-8. (2008)

2）Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M and Suematsu M. Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 100(6): 355-63. (2008)

3）Merrett K, Fagerholm P, McLaughlin CR, Dravida S, Lagali N, Shinozaki N, Watsky MA, Munger R, Kato Y, Li F, Marmo CJ and Griffith M. Tissue-engineered recombinant human collagen-based corneal substitutes for implantation: performance of type I versus type Ⅲ collagen. Invest. Ophthalmol. Vis. Sci. 49(9):3887-94. (2008)

4）Arakawa T, Niikura T, Arisaka F and Kita Y. Activity-dependent neurotrophic factor, ADNF, determines the syructure characteristics of Colivelin, a fusion protein of ADNF9 and Humanin analog. J. Pept. Sci. 14(5):631-6. (2008)

5）Arakawa T, Kita Y and Koyama AH. Solubility enhancement of gluten and organic compounds by arginine. Int. J. Pharm. 355(1-2):220-3. (2008)

6）Kita Y, Niikura T, Arisaka F and Arakawa T. The complex structure transition of Humanin peptides by sodium dodecylsulfate and trifluoroethanol. Protein. Pept. Lett. 15(5):510-5. (2008)

7）Arisaka F, Niikura T, Arakawa T and Kita Y. The structure analysis of Humanin analog, AGA-(C8R)HNG17, by circular dichroism and sedimentation equilibrium: comparison with the parent molecule. Int. J. Biol. Macromol. 43(2):88-93. (2008)

8）Arakawa T, Kita Y, Ejima D and Gagnon P. Solvent modulation of column chromatography. Protein. Pept. Lett. 15(6):544-55. (2008)

9）Arakawa T, Kita Y and Niikura T. A rescue factor for Alzheimer's diseases: discovery, activity, structure, and mechanism. Curr. Med. Chem. 15(21):2086-98. (2008)

10）Nomoto Y, Kobayashi K, Tada Y, Wada I, Nakamura T and Kmori K. Effect of fibroblasts on epithelial regeneration on the surface of a bioengineered trachea. Ann. Otol. Rhinol. Laryngol. 117(1):59-64. (2008)

11）Tada Y, Suzuki T, Takezawa T, Nomoto Y, Kobayashi K, Nakamura T and Omori K. Regeneration of tracheal epithelium utilizing a novel bipotential collagen scaffold. Ann. Otol. Rhinol. Laryngol. 117(5):359-65. (2008)

12）Suzuki T, Kobayashi K, Tada Y, Suzuki Y, Wada I, Nakamura T and Omori K. Regeneration of the tranchea using a bioengineered scaffold with adipose-derived stem cells. Ann. Otol. Rhinol. Laryngol. 117(6):453-63. (2008)

13）Omori K, Tada Y, Suzuki T, Nomoto Y, Matsuzaka T, Kobayashi K, Nakamura T, Kanamaru S, Yamashita M and Asato R. Clinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea. Ann. Otol. Rhinol. Laryngol. 117(9):673-8. (2008)

14）Ikeshima-Kataoka H, Shen JS, Eto Y, Saito S and Yuasa S. Alteration of inflammatory cytokine production in the injured central nervous system of tenascin-deficient mice. In. Vivo. 22(4):4019-13. (2008)

15）Ikeshima-Kataoka H and Yuasa S. Selective ablation of an astroglial subset by toxic gene expression driven by tenascin promoter. Neurol. Res. 30(7):701-9. (2008)

16）Wu X, Yang Y, Gui P, Sohma Y, Meininger GA, Davis GE, Braun AP and Davis MJ. Potentiation of large conduvtance, Ca2+-activated K+(BK) channels by alpha5beta1 integrin activation in arteriolar smooth muscle. J. Physiol. 586(6):1699-713. (2008)

17）Mori Y, Yoshida H, Miyamoto M, Sohma Y and Kubota T. Constitutive activity of inwardly rectifying K+ channel at physiological (Ca)i is mediated by Ca2+/CaMK Ⅱ pathway in opossum kidney proximal tubule cells. J. Physiol. Sci. 58(3):199-207. (2008)

18）Mio K, Ogura T, Mio M, Shimizu H, Hwang TC, Sato C and Sohma Y. Three-dimensional reconstruction of human vystic fibrosis transmembrane conductance regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transmembrane domain. J. Biol. Chem. 283(44):30300-10. (2008)

19）Abe Y, Kita Y and Niikura T. Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog. 275(2):318-31. (2008)

20）Thomas GM, Lin DT, Nuriya M and Huganir RL. Rapid and bi-directional regulation og AMPA receptor phosphorylation and trafficking by JNK. EMBO. J. 27(2):361-72. (2008)

2007

1）Sasaki Y, Tsubota K, Kawedia JD, Menon AG and Yasui M. The difference of aquaporin 5 distribution in acinar and ductal cells in lacrimal and parotid glands. Curr. Eye. Res. 32(11): 923-9. (2007)

2）Nagase H, Agren J, Saito A, Liu K, Agre P, Hazama A and Yasui M. Molecular cloning and characterization of mouse aquaporin-6. Biochem. Biophys. Res. Commun. 352(1):12-6. (2007)

3）Kato N, Akai M, Zulkifli L, Matsuda N, Kato Y, Goshima S, Hazama A, Yamagami M, Guy HR and Uozumi N. Role of positively charged amino acids in the M2D transmembrane helix of Ktr/ Trk/ HKT type cation transporters. Channels.(Austin) 1(3):161-71. (2007)

4）Kobayashi K, Suzuki T, Nomoto Y, Tada Y, Miyake M, Hazama A, Nakamura T andOmori K. Potential of heterotopic fibroblasts as autologous transplanted cells for tracheal epithelial regeneration. Tissue. Eng 13(9):2175-84. (2007)

5）Arakawa T, Tsumoto K, Ejima D, Kita Y, Tonezawa Y and Tokunaga M. Induced binding of proteins by ammonium sulfate in affinity and ion-exchange column chromatography. J. Biochem. Biophys. Methods. 70(3):493-8. (2007)

6）Arakawa T, Ejima D, Tsumoto K, Obeyama N, Tanaka Y, Kita Y and Timasheff SN. Suppression of protein interactions by arginine : a proposed mechanism of the arginine effects. Biophys. Chem. 127(1-2):1-8. (2007)

7）Tsumoto K, Ejima D, Senczuk AM, Kita Y and Arakawa T. Effects of salts on protein-surface interactions : applications for column chromatography. J. Pharm. Sci. 96(7):1677-90. (2007)

8）Arakawa T, Tsumoto K, Kita Y, Chang B and Ejima D. Biotechnology applications of amino acids in protein purification and formulations. Amino. Acids. 33(4):587-605. (2007)

9）Arakawa T, Niikura T, Tajima H, Arisaka F and Kita Y. Structure analysis of activity-dependent neurotrophic favtor 9 by circular dichroism and sedimentation equilibrium. J. Mol. Neurosci. 33(3):262-7. (2007)

2006

1）Beitz E, Liu K, Ikeda M, Guggino WB, Agre P and Yasui M. Determinants of AQP6 trafficking to intracellular sites versus the plasma membrane in transfected mammalian cells. Biol. Cell. 98(2): 101-9. (2006)

2）Otani H, Matsuhisa S, Akita Y, Kyoi S, Enoki C, Taysumi K, Fujiwara H, Hattori R, Imamura H and Iwasaka T. Role of mechanical stress in the form of cardiomyocyte death during the early phase of reperfusion. Circ. J. 70(10):1344-55. (2006)

3）Nomoto Y, Suzuki T, Tada Y, Kobayashi K, Miyake M, Hazama A, Wada I, Kanemaru S, Nakamura T and Omori K. Tissue engineering for regeneration of the tracheal epithelium. Ann. Otol. Rhinol. Laryngol. 115(7):501-6. (2006)

4）Kobayashi K, Nomoto Y, Suzuki T, Tada Y, Miyake M, Hazama A, Kanemaru S, Nakamura T and Omori K. Effect of fibroblasts on tracheal epithelial regeneration in vitro. Rissue. Eng. 12(9):2619-28. (2006)

5）Hayakawa T, Hirano Y, Makino A, Michaud S, Lagarde M, Pageaux JF, Doutheau A, Ito K, Fujisawa T, Takahashi H and Kobayashi T. Differentiol membrane packing of stereoisomers of bis (monoacylglycero) phosphate. Biochemistry. 45(30):9198-209. (2006)

6）Niikura T, Tajima H and Kita Y. Neuronal cell death in Alzheimer's Disease and a neuroprotective factor, humanin. Curr. Neuropharmacol. 4(2):139-47. (2006)

7）Arakawa T, Ejima D, Kita Y and Tsumoto K. Small molecule pharmacological chaperones : From thermodynamic stabilization to pharmaceutical drugs. Biochim. Biophys. Acta. 1764(11):1677-87. (2006)

8）Arakawa T, Kita Y, Ejima D, Tsumoto K and Fukada H. Aggregation suppression of proteins by arginine during thermal unfolding. Protein. Pept. Lett. 13(9):921-7. (2006)

9）Arakawa T, Niikura T, Tajima H and Kita Y. The secondary structure analysis of a potent Ser14Gly analog of antiAlzheimer peptide, Humanin, by circular dichroism. J. Pept. Sci. 12(10):639-42. (2006)

10）Nuriya M, Jiang J, Nemet B, Eisenthal KB and Yuste R. Imaging membrane potential in dendritic spines. Proc. Natl. Acad. Sci. U.S.A. 103(3):786-90. (2006)

11）Nuriya M and Huganir RL. Regulation of AMPA receptor trafficking by N-cadherin. J. Neurochem. 97(3):652-61. (2006)

12）Nagase H, Agren J, Saito A, Liu K, Agre P, Hazama A and Yasui M. Molecular cloning and characterization of mouse aquaporin 6. Biochem. Biophys. Res. Commun. 352(1):12-6. (2006)

2005

1）Ishikawa Y, Yuan Z , Inoue N, Skowronski MT, Nakae Y, Shono M, Cho G, Yasui M, Agre P and Nielsen S. Identification of AQP5 in lipid rafts and its translocation to apical membranes by activation of M3-mAChRs in interlobular ducts of rat parotid glands. Am. J. Physiol.Cell.Physiol. 289(5):C1303-11. (2005)

2）Liu K, Kozono D, Kato Y, Agre P, Hazama A and Yasui M. Conversion of aquaporin-6 from an anion channel to a water-selective channel by a single amino acid substitution. Proc. Natl. Acad. Sci. USA. 102(6): 2192-7. (2005)

3）Ohashi R, Takaya J, Tsuji S, Yamato F, Hasui M, Kinoshita Y and Kobayashi Y. Prognostic usefulness of lymphocyte V beta receptor determination in toxic shock syndrome. Eur. J. Pediatr. 164(11):703-4. (2005)

4）Kobayashi K, Fukunaga S, Takenouchi K, Akato-Mori Y and Nakamura F. Functional role of type VI collagen during early feather development of the chicken embryo in vitro. Animal. Sci. J. 76:273-82. (2005)

5）Hata M, Hirano Y, Hoshino T, Nishida R and Tsuda M. Theoretical study on monooxygenation mechanism by cytochrome P450 : an ultimate species in the substrate oxidation process. J. Mol. Struct.(Theochem) 722(2):133-37. (2005)

6）Hirano Y, Shinmoto N, Hata M, Tsuda M and Hoshino T. Quantum chemical study on the deacylation step of human chymase. J. Mol. Struct.(Theochem) 757(30):19-27. (2005)

7）Nagayoshi C, Ishibashi M, Kita Y, Matsuoka M, Nishimoto I and Tokunaga M. Expression, refolding and characterization of human brain serine racemase in Escherichia coli with N-terminal His-tag. Protein. Pept. Lett. 12(5):487-90. (2005)

8）Tajima H, Kawasumi M, Chiba T, Yamada M, Yamashita K, Nawa M, Kita Y, Kouyama K, Aiso S, Matsuoka M, Niikura T and Nishimoto I. A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice. J. Neurosci. Res. 79(5):714-23. (2005)

9）Obata Y, Niikura T, Kanekura K, Hashimoto Y, Kawasumi M, Kita Y, Aiso S, Matsuoka M and Nishimoto I. Expression of N19S-SOD1, an SOD1 mutant found in sporadic amyotrophic lateral sclerosis patients, induces low-grade motoneuronal toxicity. J. Neurosci. Res. 81(5):720-9. (2005)

10）Yamada M, Chiba T, Sasabe J, Nawa M, Tajima H, Niikura T, Terashita K, Aiso S, Kita Y, Matsuoka M and Nishimoto I. Implanted cannula-mediated repetitive administration of Abeta25-35 into the mouse cerebral ventricle effectively impairs spatial working memory. Behav. Brain. Res. 164(2):139-46. (2005)

11）Chiba T, Yamada M, Hashimoto Y, Sato M, Sasabe J, Kita Y, Terashita K, Aiso S, Nishimoto I and Matsuoka M. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus : characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo. J. Neurosci. 25(44):10252-61. (2005)

12）Nuriya M, Oh S and Huganir RL. Phosphorylation-dependent interactions of alpha-Actinin-1/IQGAP1 with the AMPA receptor subunit GluR4. J. Neurochem. 95(2):544-52. (2005)

13）Kanekura K, Hashimoto Y, Kita Y, Sasabe J, Aiso S, Nishimoto I and Matsuoka M. A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death. J. Biol. Chem. 280(6):4532-43. (2005)

2004

1）Yasui M. Molecular mechanisms and drug development in aquaporin water channel diseases: structure and function of aquaporins. J. Pharmacol. Sci. 96(3): 260-3. (2004)

2）Beitz E, Pavlovic-Djuranovic S, Yasui M, Agre P and Schultz JE. Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis. Proc. Natl. Acad. Sci. USA. 101(5): 1153-8. (2004)

3）Hasui M, Sasaki M, Tsuji S, Yamamoto A, Takaya J, Taniuchi S, Izumi H, Hagihara T, Daito M and Kobayashi Y. Dental infections as a cause of persistent fever in a patient with chronic granulomatous disease. Clin. Pediatr. (Phila) 43(2):171-3. (2004)

4）Kobayashi K, Fukunaga S, Takenouchi K and Nakamura F. Functional indispensability of fibronectin associated on the mesenchymal cell surface during the early period of feather development in the chick embryo in vitro. Animal. Sci. J. 75(5):441-9. (2004)

5）Suenaga A, Liyatkin AB, Hatakeyama M, Futatsugi N, Okimoto N, Hirano Y, Narumi T, Kawai A, Susukita R, Koishi T, Furusawa H, Yasuoka K, Takada N, Ohno Y, Taiji M, Ebizaki T, Hoek JB, Konagaya A and Kholodenko BN. Tyr-317 phosphorylation increases Shc structural rigidity and reduces coupling of domain motions remote from the phosphorylation site as revealed by molecular dynamics simulations. J. Biol. Chem. 279(6):4657-62. (2004)

6）Hata M, Hirano Y, Hoshino T, Nishida R and Tsuda M. Theoretival study on Compound I Formation in Monooxygenation Mechanism by Cytochrome P450. J. Phys. Chem. B. 108(30):11189-95. (2004)

7）Okimoto N, Nakamura T, Suenaga A, Futatsugi N, Hirano Y, Yamaguchi I and Ebisuzaki T. Cooperative motions of protein and hydration water molecules : molecular dynamics study of scytalone dehydratase. J. Am. Chem. Soc. 126(40):13132-9. (2004)

8）Abe Y, Hashimoto Y, Tomita Y, Terashita K, Aiso S, Tajima H, Niikura T, Matsuoka M and Nishimoto I. Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant. J. Neurosci. Res. 77(4):583-95. (2004)

9）Hashimoto Y, Kaneko Y, Tsukamoto E, Frankowski H, Kouyama K, Kita Y, Niikura T, Aiso S, Bredesen DE, Matsuoka M and Nishimoto I. Molecular characterization of neurophybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD. J. Neurochem. 90(3):549-58. (2004)

10）Hashimoto Y, Terashita K, Niikura T, Yamagishi Y, Ishizaka M, Kanekura K, Chiba T, Yamada M, Kita Y, Aiso S, Matsuoka M and Nishimoto I. Humanin antagonists : mutants that interfere with dimerization inhibit neuroprotection by Humanin. Eur. J. Neurosci. 19(9):2356-64. (2004)

11）Vhiba T, Hashimoto Y, Tajima H, Yamada M, Kato R, Niikura T, Terashita K, Schulman H, Aiso S, Kita Y, Matsuoka M and Nishimoto I. Neuroprotective effect of activity-dependent neurotrophic factor against toxicity from familial amyotrophic lateral sclerosis-linked mutant SOD1 in vitro and in vivo. J. Neurosci. Res. 78(4):542-52. (2004)

12）Gomes AR, Cunha P, Nuriya M, Faro CJ, Huganir RL, Pires EV, Carvalho AL and Duarte CB. Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activity through PKA in cultured chick retinal neurons : effect on GluR4 phosphorylation and surface expression. J. Neurochem. 90(3):673-82. (2004)

2003

1）Komatsu Y, Yukutake Y and Yoshida M. Four different clones of mouse anti-acetyllysine monoclonal antibodies having different recognition properties share a common immunoglobulin framework structure. J. Immunol. Methods. 272(1-2):161-75. (2003)

2）Okimoto N, Yamanaka K, Suenaga A, Hirano Y, Futatsugi N, Narumi T, Yasuoka K, Susukita R, Koishi T, Furusawa H, Kawai A, Hata M, Hoshino T and Ebisyzaki T. Molecular dynamics simulations of prion proteins effect of Ala117. Chem. Bio. Informatics. J. 3(1)1-11. (2003)

3）Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Sakurai T and Goto K. Orexin receptor type-1 coupls exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. J. Pharmacol. Sci. 92(3):259-66. (2003)

4）Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuika M, Niikura T, Aiso S, Kita Y, Iwatsubo T and Nishimoto I. Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol. J. Neurosci. 23(24):8513-25. (2003)

5）Terashita K, Hashimoto Y, Niikura T, Tajima H, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Nawa M, Kita Y, Aiso S and Nishimoto I. Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity : functional potentiation by isomerization and dimerization. J. Neurochem. 85(6):1521-38. (2003)

6）Yokoyama K, Ejima D, Kita Y, Philo JS and Arakawa T. Structure of folding intermediates at pH 4.0 and native state of microbial transglutaminase. Biosci. Biotechnol. Biochem. 67(2):291-4. (2003)

7）Yokoyama K, Ohtsuka C, Kuraishi K, Ono Y, Kita Y and Ejima D. Gelation of food protein induced by recombinant microbial transglutaminase. J. Food. Sci. 68(1):48-51. (2003)

8）Esteban JA, Shi SH, Wilson C, Nuriya M, Huganir RL and Malinow R. PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Nat. Neurosci. 6(2):136-43. (2003)

2002

1）Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P and Yasui M. Characterization of aquaporin-6 as a nitrate channel in mammalian cells: Requirement of pore-lining residue threonine-63. J. Biol. Chem. 277(42):39873-9. (2002)

2）King LS and Yasui M. Aquaporins and disease: lessons from mice to humans (review). Trends Endocrinol. Metab. 13(8):355-60. (2002)

3）Hazama A, Kozono D, Guggino WB, Agre P and Yasui M. Ion permeation of AQP6 water channel protein. Single channel recordings after Hg2+ activation. J. Biol. Chem. 277(32):29224-30. (2002)

4）Kozono D, Yasui M, King LS and Agre P. Aquaporin Water Channels: Atomic Structure and Molecular Dynamics meet Clinical Medicine (review). J. Clin. Invest. 109(11):1395-99. (2002)

5）Agre P, King LS, Yasui M, Guggino WB, Ottersen OP, Fujiyoshi Y, Engel A and Nielsen S. Aquaporin Water Channels-From Atomic Structure to Clinical Medicine (review). J. Physiol. 542(Pt1): 3-16. (2002)

6）Hasui M, Kotera F, Tsuji S, Yamamoto A, Taniuchi S, Fujikawa Y, Nakajima M, Yoshioka A and Kobayashi Y. Successful resumption of trimethoprim-sulfamethoxazole after oral desensitization in patients with chronic granulomatous disease. Eur. J. Pediatr. 161(6):356-7. (2002)

7）Yamamoto A, Taniuchi S, Tsuji S, Hasui M and Kobayashi Y. Role of reactiveoxygen species in neutrophil apoptosis following ingestion of heat-killed Staphylococcus aureus. Clin. Exp. Immunol. 129(3):479-84. (2002)

8）Tsuji S, Taniuchi S, Hasui M, Yamamoto A and Kobayashi Y. Increased nitric oxide production by neutrophils from patients with chronic granulomatous disease on trimethoprim-sulfamethoxazole. Nitric. Oxide. 7(4):283-8. (2002)

9）Taniuchi S, Masuda M, Hasui M, Ysuji S, Takahashi H and Kobayashi Y. Differential diagnosis and clinical course of autoimmune neutropenia in infancy : comparison with congenital neutropenia. Acta. Paediatr. 91(11):1179-82. (2002)

10）Nakamura F, Seki I, Kobayashi K, Tanaka M, Fukunaga S. Immunohistochemical detection of cellular prion protein (PrPc) in the rat central nervous system. Animal. Sci. J. 73(6):553-6. (2002)

11）Hirano Y, Hata M, Hoshino T and Tsuda M. Quantum chemical study on the catalytic mechanism of cAMP-dependent protein kinase. J. Phys. Chem. 116:5788-92. (2002)

12）Hashimoto Y, Niikura T, Ito Y, Kita Y, Terashita K and Mishimoto I. Neurotoxic mechanisms by Alzheimer'S disease-linked N141I mutant presenilin 2. J. Pharmacol. Exp. Ther. 300(3):736-45. (2002)

13）Hashimoto Y, Ito Y, Arakawa E, Kita Y, Terashita K, Niikura T and Nishimoto I. Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1 : involvement of NO synthase via a novel pertussis toxin target. J. Neurochem. 80(3):426-37. (2002)

14）Kita Y and Arakawa T. Salts and glycine increase reversibility and decrease aggregation during thermal unfolding of ribonuclease-A. Biosci. Biotechnol. Biochem. 66(4):880-2. (2002)

15）Tajima H, Niikura T, Hashimoto Y, Ito Y, Kita Y, Terashita K, Yamazaki K, Kato A, Aiso S and Nishimoto I. Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. Neurosci. Lett. 324(3):27-31. (2002)

2001

1）Agre P, Borgnia M J, Yasui M, Neely, J.D., Carbrey, J., Kozono, D., Beitz, E., Langloh, A.L., Hoffert, J., Leitch, V. and King, L.S. Discovery of the aquaporins and their impact on basic and clinical physiology. Current Topics in Membranes. Hohmann, Nielsen, Agre, eds. Pp.1-38. (2001)

2）Taniuchi S, Masuda M, Yamamoto A, Hasui M, Tsuji S, Komiyama Y, Takahashi H and Kobayashi Y. FcgammaRⅢb and FcgammaRⅡa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy. Hum. Immunol. 62(4):408-13. (2001)

3）Taniuchi S, Yamamura S, Tsuji S, Hasui M, Ohtani T, Nomura S and Kobayashi Y. A convenient method of granulocyte transfusion using a hydroxylethyl starch (HESPAN) containing a bag. Pediatr. Hematol. Oncol. 18(4):299-301. (2001)

4）Hata M, Hirano Y, Hoshino T and Tsuda M. Monooxygenation mechanism by cytochrome p-450. J. Am. Chem. Soc. 123(26):6410-6. (2001)

5）Hata M, Hirano Y, Hoshino T and Tsuda M. Origin of the primary kinetic hydrogen isotope effects on N-dealkylation from N-alkilamine by hemoproteins. Bulletin. Chem. Sci. J. 74:1577-83. (2001)

6）Niikura T, Hashimoto Y, Okamoto T, Abe Y, Yasukawa T, Kawasumi M, Hiraki T, Kita Y, Terashita K, Kouyama K and Nishimoto I. Insulin-like growth factor 1 (IGF-1) protects cells from apoptosis by Alzheimer's V6421 mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner. J. Neurosci. 21(6):1902-10. (2001)

7）Hashimoto Y, Niikura T, Ito Y, Sudo H, Hata M, Arakawa E, Abe Y, Kita Y and Nishimoto I. Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults. J. Neurosci. 21(23):9235-45. (2001)

8）Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K and Nishimoto I. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc. Natl. Acad. Sci. U.S.A. 98(11):6336-41. (2001)

9）Wen J, Zhang M, Horan TP, Philo JS, Li T, Wypych J, Mendiaz EA, Langley KE, Aoki KH, Kuwamoto M, Kita Y and Arakawa T. Copper staining method for extracting biologically active proteins from native gels. Biosci. Biotechnol. Biochem. 65(6):1315-20. (2001)

10）Arakawa T, Philo JS and Kita Y. Kinetic and thermodynamic analysis of thermal unfolding of recombinant erythropoietin. Biosci. Biotechnol. Biochem. 65(6):1321-7. (2001)

11）Matsuda S, Yasukawa T, Homma Y, Ito Y, Niikura T, Hirai S, Ohno S, Kita Y, Kawasumi M, Kouyama K, Yamamoto T, Kyriakis JM and Nishimoto I. c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J. Neurosci. 21(17):6597-607. (2001)

12）Hashimoto Y, Niikura T, Ito Y, Sudo H, Hata M, Arakawa E, Abe Y, Kita Y and Nishimoto I. Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults. J. Neurosci. 21(23):9235-45. (2001)

2000

1）Promeneur D, Kwon TH, Yasui M, Kim GH, Frokier J, Knepper M A, Agre P and Nielsen S. Regulation of AQP6 mRNA and protein expression in rats in response to altered acid-base or water load balasnce. Am. J. Physiol.Renal.Physiol. 279(6): F1014-26.

2）Francis P, Chung JJ, Yasui M, Berry V, Moore A, Wyatt MK, Wistow G, Bhattacharya SS and Agre P. Functional impairment of lens aquaporin in two families with dominantly inherited cataracts. Hum. Mol. Genet. 9 (15):2329-34.

3）King LS, Yasui M and Agre P. Aquaporins in health and disease (review). Mol. Med. Today. 6(2):60-5. (2000)

4）Ohuchi H, Suzuki H, Toyohara K, Tatsumi K, Ono Y, Arakaki Y and Echigo S. Abnormal cardiac autonomic nervous activity after right ventricular outflow tract reconstruction. Circulation. 102(22):2732-8.

5）Taniuchi S, Masuda M, Yamamoto A, Hasui M, Tsuji S, Takahashi H and Kobayashi Y. Two cases of autoimmune neutropenia possibly induced by beta-lactam antibiotics in infants. J. Pediatr. Hematol. Oncol. 22(6):533-8.

6）Hirano Y, Ohmori N, Okimoto N, Hata M, Hoshino T and Tsuda M. The importance of OH groups containing solid films for high sensitivity of chemically amprified resists. J. Photopolmer. Sci. Techno. 13(4):503-6. (2000)

7）Hirano Y, Hata M, Hoshino T and Tsuda M. Mechanism of phosphorylation of serresidue catalyzed by cAMP dependent protein kinase. JCPE. J. 12(2):119-28.

8）Abe Y, Nakayama K, Yamanaka A, Sakurai T and Goto K. Subtype-specific trafficking of endothelin receptors. J. Bio. Chem. 275(12):8664-71.

9）Abe Y, Sakurai T, Yamada T, Nakamura Y, Yanagisawa M and Goto K. Functional analysis of five endothelin-B receptor mutations found in human Hirschsprung disease patients. Biochem. Biophys. Res. Commun. 275(2):524-31. (2000)

10）Hashimoto Y, Jiang H, Niikura T, Ito Y, Hagiwara A, Umezawa K, Abe Y, Murayama Y and Nishimoto I. Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTP ases. J. Neurosci. 20(22):8401-9.

11）Arakawa T and Kita Y. Refractive index of proteins in organic solvents. Anal. Biochem. 271(1):119-20. (2000)

12）Arakawa T and Kita Y. Stabilizing effects of caprylate and acetyltryptophanate on heat-induced aggregation of bovine serum albumin. Biochim. Biophys. Acta. 1479(1-2):32-6.

13）Arakawa T and Kita Y. Protection of bovine serum albumin from aggregation by Tween 80. J. Pharm. Sci. 89(5):646-51.

14）Hagiwara A, Hashimoto Y, Niikura T, Ito Y, Terashita K, Kita Y, Nishimoto I and Umezawa K. Neuronal cell apoptosis by a receptor-binding domain peptide of ApoE4, not through low-density lipoprotein receptor-related protein. Biochem. Biophys. Res. Commun. 278(3):633-9.

15）Beneken J, Tu JC, Xiao B, Nuriya M, Yuan JP, Worley PE and Leahy DJ. Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron. 26(1):143-54.

1999

1）Yasui M, Hazama A, Kwon TH, Nielsen S, Guggino WB and Agre P. Rapid gating and anion permeability of an intracellular aquaporin. Nature. 402(6758): 184-7.

2）Yasui M, Kwon TH, Knepper MA, Nielsen S and Agre P. Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia. Proc. Natl. Acad. Sci. USA. 96(10):5808-13.

3）Nishimoto G, Zelenina M, Li D, Yasui M, Aperia A, Nielsen S and Nairn AC. Arginine vasopressin stimulates phosphorylation of aquaporin-2 in rat renal tissue. Am. J. Physiol. 276(2Pt2):F254-9.

4）Caughey DJ, Narhi LO, Kita Y, Meng SY, Wen D, Chen W, Ratzkin BJ, Fujimoto J, Iwahara T, Yamamoto T and Arakawa T. Fractionation of polyclonal antibodies to fragments of a neuroreceptor using three increasingly chaotropic solvents. J. Chromatogr. B. Biomed. Sci. Appl. 728(1):49-57.

5）Hirano Y, Ohmori N, Hata M, Hoshino T and Tsuda M. On the origin of photochemically generated protons in polymethacrylate films. A new structure of PAG. J. Photopolym. Sci. Technol. 12:637-40.

6）Taniuchi S, Yamamoto A, Fujiwara T, Hasui M, Tsuji S and Kobayashi Y. Dizygotic twin sisters with myelokathexis : mechanism of its neutropenia. Am. J. Hematol. 62(2):106-11.

1998

1）Lecoin L, Sakurai T, Ngo MT, Abe Y, Yanagisawa M and Le Douarin NM. Cloning and characterization of a novel endothelin receptor subtype in the avian class. Proc. Natl. Acad. Sci. U.S.A. 95(6):3024-9.

1997

1）Yasui M, Serlachius E, Lofgren M, Belusa R, Nielsen S and Aperia A. Perinatal changes in expression of aquaporin-4 and other water and ion transporters in rat lung. J. Physiol. (London). 505(Pt1): 3-11.

2）Yasui M, Zelenin SM, Celsi G and Aperia A. Adenylate cyclase-coupled vasopressin receptor activates AQP2 promoter via a dual effect on CRE and AP1 elements. Am. J. Physiol. 272(4Pt2):F443-F50.

3）Kita Y and Arakawa T. NDF and erbB2, erbB3 and erbB4. Experimental. Medicine (Japanese). 159(9):98-100.

4）Narhi LO, Caughey DJ, Horan TP, Kita Y, Chang D and Arakawa T. Fractionation and characterization of polyclonal antibodies using three progressively more chaotropic solvents. Anal. Biochem. 253(2):246-52.

Department of Pharmacology, Keio University School of Medicine

reaserch result